Best Sequel to an Awesome Game Ever

Resident Evil 4 (Gamecube)
This game has the best graphics of any game on any system of the last generation. Not only does it have great graphics, but it has a tremendous story line and great replay value. Resident Evil 4 revolutionized the way you play Resident Evil games. No more moving around like a tank and shooting hoping you'll hit the zombie. The shooting is precise, and the characters are creative and creepy. It's not the scariest survival game ever, but it is the best.
Honorable Mention:
Turtles 3: The Manhattan Project
Call of Duty 4
Donkey Kong Country 2